Pathogen's role in disease

Some microorganisms like Staphylococcus, Streptococcus, Yesinia pestis, E. coli can cause diseases of different body systems. Let's investigate how the same pathogen is responsible for different pathophysiological symptoms. First, choose a microorganism found in multiple systems. Then, describe your pathogen's role in disease for one body system: report the disease caused, the normal function of that system, pathophysiological symptoms, and the virulence factor(s) that contribute(s) to the diseased state.